Research articles

Microbiota Sensing by Mincle-Syk Axis in Dendritic Cells Regulates Interleukin-17
and -22 Production and Promotes Intestinal Barrier Integrity.
Martínez-López M, Iborra S, Conde-Garrosa R, Mastrangelo A, Danne C, Mann ER, Reid DM,
Gaboriau-Routhiau V, Chaparro M, Lorenzo MP, Minnerup L, Saz-Leal P, Slack E,
Kemp B, Gisbert JP, Dzionek A, Robinson MJ, Rupérez FJ, Cerf-Bensussan N,
Brown GD, Bernardo D, LeibundGut-Landmann S, Sancho D.
Immunity. 2019 Jan 21. pii: S1074-7613(18)30568-5. doi:10.1016/j.immuni.2018.12.020. [Epub ahead of print]

The fungal ligand chitin directly binds TLR2 and triggers inflammation dependent on oligomer size. Katharina Fuchs, Yamel Cardona Gloria1, Olaf-Oliver Wolz, Franziska Herster, Lokesh Sharma, Carly A Dillen, Christoph Täumer, Sabine Dickhöfer, Zsofia Bittner, Truong-Minh Dang, Anurag Singh, Daniel Haischer, Maria A Schlöffel, Kirsten J Koymans, Tharmila Sanmuganantham, Milena Krach, Thierry Roger, Didier Le Roy, Nadine A Schilling, Felix Frauhammer, Lloyd S Miller, Thorsten Nürnberger, Salomé LeibundGut-Landmann,
Andrea A Gust, Boris Macek, Martin Frank, Cécile Gouttefangeas, Charles S Dela Cruz, Dominik Hartl, Alexander NR Weber
EMBO Rep. 2018 Dec;19(12). pii: e46065. doi: 10.15252/embr.201846065. Epub 2018 Oct 18.


IL-17 Takes Center Stage in Dermatophytosis. Florian Sparber, Salomé LeibundGut-Landmann. j.jid.2018.03


Common Features of Regulatory T Cell Specialization During Th1 Responses.

Katharina Littringer, Claudia Moresi, Nikolas Rakebrandt, Xiaobei Zhou, Michelle Schorer, Tamas Dolowschiak, Florian Kirchner, Felix Rost, Christian W. Keller, Donal McHugh, Salomé LeibundGut-Landmann, Mark D. Robinson and Nicole Joller. Front. Immunol., 13 June 2018


Langerin+ DCs regulate innate IL-17 production in the oral mucosa during Candida albicans-mediated infection.

Sparber F, Dolowschiak T, Mertens S, Lauener L, Clausen BE, Joller N, Stoitzner P, Tussiwand R, LeibundGut-Landmann S, PLoS Pathog. 2018 May 21


Identification of Candida albicans regulatory genes governing mucosal infection.

Juliane Meir, Elena Hartmann, Marie-Therese Eckstein, Eva Guiducci, Florian Kirchner, Andreas Rosenwald, Salomé LeibundGut-Landmann, J. Christian Pérez.


Modulation of the Fungal-Host Interaction by the Intra-Species Diversity of C. albicans.

Braunsdorf Christina, LeibundGut-Landmann Salomé


Host Responses to Malassezia spp. in the Mammalian Skin

Florian Sparber, Salomé LeibundGut-Landmann


The intraspecies diversity of C. albicans triggers qualitatively and temporally distinct host responses that determine the balance between commensalism and pathogenicity.

Schönherr FA, Sparber F, Kirchner FR, Guiducci E, Trautwein-Weidner K, Gladiator A, Sertour N, Hetzel U, Le GTT, Pavelka N, d'Enfert C, Bougnoux ME, Corti CF, LeibundGut-Landmann S.

Mucosal Immunol. 2017 Sep;10(5):1335-1350. doi: 10.1038/mi.2017.2. Epub 2017 Feb 8. PMID:28176789


The two-component response regulator Skn7 belongs to a network of transcription factors regulating morphogenesis in Candida albicans and independently limits morphogenesis-induced ROS accumulation.

Basso V, Znaidi S, Lagage V, Cabral V, Schoenherr F, LeibundGut-Landmann S, d'Enfert C, Bachellier-Bassi S.

Mol Microbiol. 2017 Oct;106(1):157-182. doi: 10.1111/mmi.13758. Epub 2017 Aug 22.PMID:28752552


Schönherr FA, Sparber F, Kirchner FR, Guiducci E, Trautwein-Weidner K, Gladiator A, Sertou N, Hetzel U, Le GTT, Pavelka N, d’Enfert C, Bougnoux ME, Fragoso Corti C, LeibundGut-Landmann S. 2017. The intraspecies diversity of C. albicans triggers qualitatively and temporally distinct host 1 responses that determine the balance between commensalism and pathogenicity. Mucosal Immunology. doi: 10.1038/mi.2017.2

Müller AA, Dolowschiak T, Sellin ME, Felmy B, Verbree C, Gadietn S, Westermann A, Vogel J, LeibundGut-Landmann S, Hardt WD. 2016. An NK cell perforin response elicited via IL-18 controls mucosal inflammation kinetics during Salmonella gut infection. PLoS Pathogens. 12(6): e1005723

Stuehler C, Bernardini C, Elzi L, Stockle M, Zimmerli S, Furrer H, Günthard HF, LeibundGut-Ladmann S, Battegay M, Khanna N and the Swiss HIV Cohort Study. 2016. Immune recovery in HIV-infected patients after Candida esophagitis is impaired despite long-term antiretroviral therapy. AIDS. 30(12):1923-33

Altmeier S, Toska A, Sparber F, Teijeira A, Halin C and LeibundGut-Landmann S. 2016. IL-1 Coordinates the Neutrophil Response to C. albicans in the Oral Mucosa. PLoS Pathog 12(9): e1005882 

Trautwein-Weidner K*, Gladiator A*, Kirchner FR, Becattini S, Rülicke T, Sallusto F and Leibundgut-Landmann S. 2015. Antigen-Specific Th17 Cells Are Primed by Distinct and Complementary Dendritic Cell Subsets in Oropharyngeal Candidiasis. PLoS Pathog 11(10): e1005164 [[* equal contribution] 

Trautwein-Weidner K*, Gladiator A*, Nur S, Diethelm P, Leibundgut-Landmann S. 2015. IL-17-mediated antifungal defense in the oral mucosa is independent of neutrophils. Mucosal Immunology, 8: 221 [* equal contribution]

Whitney PG*, Bär E*, Osorio F, Rogers NC, Schraml BU, Deddouche S, LeibundGut-Landmann S†, Reis E Sousa C†. 2014. Syk signaling in dendritic cells orchestrates innate resistance to systemic fungal infection. PLoS Pathog. 10(7):e1004276. [*,†: equal contribution ]

Dubrot J, Duraes FV, Potin L, Capotosti F, Brighouse D, Suter T, LeibundGut-Landmann S, Garbi N, Reith W, Swartz MA, Hugues S. 2014. Lymph node stromal cells acquire peptide-MHCII complexes from dendritic cells and induce antigen-specific CD4⁺ T cell tolerance. J Exp Med. 211(6):1153-66

Bär E, Whitney PG, Moor K, Reis E Sousa C, Leibundgut-Landmann S, IL-17 Regulates Systemic Fungal Immunity by Controlling the Functional Competence of NK Cells. Immunity. 2014. 40 (1): 117-27

Gladiator A, Wangler N, Trautwein-Weidner K, LeibundGut-Landmann S. 2013. Cutting Edge: IL-17-Secreting Innate Lymphoid Cells are Essential for Host Defense against Fungal Infection. J. Immunol. 190(2): 521-5

Vale-Silva L, Ischer F, LeibundGut-Landmann S and Sanglard D. 2013. Gain of function mutations in CgPDR1, a regulator of antifungal drug resistance in Candida glabrata, control adherence to host cells. Infect Immun., 81: 1709.

Mally M, Fontana C, LeibundGut-Landmann S, Laacisse L, Fan YY, Widmalm G and Aebi M. 2013. Glycoengineering of host mimicking type-2 LacNAc polymers and Lewis X antigens on bacterial cell surfaces. Mol. Micro., 87: 112

Bär E, Gladiator A, Bastidas S, Roschitzki B, Acha-Orbea H, Oxenius A, LeibundGut-Landmann S. 2012. A novel Th cell epitope of Candida albicans mediates protection from fungal infection. J. Immunol. 188: 5636

LeibundGut-Landmann S, Weidner K, Hilbi H and Oxenius A. 2011. Nonhematopoietic cells are key players in innate control of bacterial airway infection. J.Immunol. 186: 3130

Fettelschoss A, Kistowska M, LeibundGut-Landmann S, Beer HD, Johansen P, Senti G, Contassot E, Bachmann MF, French LE, Oxenius A, Kündig TM. 2011. Inflammasome activation and IL-1b target IL-1a for secretion as opposed to surface expression. PNAS, 2011 108:18055

LeibundGut-Landmann S, Osorio F, Brown GD and Reis e Sousa C. 2008. Stimulation of dendritic cells via the Dectin-1 / Syk pathway allows priming of cytotoxic T cell responses. Blood. 112: 4971

Osorio F, LeibundGut-Landmann S, Lochner M, Lahl K, Sparwasser T, Eberl G and Reis e Sousa C. 2008. DC activated via Dectin-1 convert regulatory T cells into Th17 producers. Eur.J.Immunol. 38: 3274

Worsley AGF #, LeibundGut-Landmann S #, Slack EC, Phng LK, Gerhardt H, Reis e Sousa C and MacDonald AS. 2008. Dendritic cell expression of the Notch ligand jagged2 is not essential for Th2 response induction. Eur.J.Immunol. 38: 1043 [# equal contribution]

LeibundGut-Landmann S, Groß O, Robinson MJ, Osorio F, Slack EC, Tsoni SV, Schweighoffer E, Tybulewicz V, Brown GD, Ruland J and Reis e Sousa C. 2007. Syk- and Card9-dependent coupling of innate immunity to induction of T helper cells that produce interleukin 17. Nat Immunol., 8: 630

Nolte M, LeibundGut-Landmann S, Joffre O and Reis e Sousa C. 2007. Dendritic cell quiescence under systemic inflammation driven by radioresistant cells in vivo. J.Exp.Med., 204: 1487

MacKay P, LeibundGut-Landmann S, Koch N, Reith W, Jack RW, McLellan A. 2006. Circulating, soluble forms of major histocompatility complex antigens are not exosome-associated. Eur.J.Immunol., 35: 2875

Otten L, Lavanchy C, Barras E, LeibundGut-Landmann S, Kos-Braun I, Huarte J, Steimle V, Acha-Orbea H, Reith W. 2006. Revisiting the specificity of the MHC class II transactivator CIITA in vivo. Eur.J.Immunol., 35: 1548

LeibundGut-Landmann S, Waldburger JM, Reis e Sousa C, Acha-Orbea H, Reith W. 2004. MHC class II expression is regulated differentially between plasmacytoid and conventional dendritic cells. Nat.Immunol., 5: 899-908

Landmann S, Mühlethaler-Mottet A, Bernasconi L, Suter T, Waldburger JM, Masternak K, Arrighi JF, Hauser C, Fontana A, Reith W. 2001. Maturation of dendritic cells is accompanied by rapid transcriptional silencing of class II transactivator (CIITA) expression. J.Exp.Med., 194: 379-391

Ludewig B, Odermatt B, Landmann S, Hengartner H, Zinkernagel RM. 1998. Dendritic cells induce autoimmune diabetes and maintain disease via de novo formation of local lymphoid tissue. J.Exp.Med., 188: 1493-1501