Selected Publications


1. Transfer of anti-rotavirus antibodies during pregnancy and in milk following maternal vaccination with an HSV-1 amplicon vector. Anita F. Meier , Mark Suter , Elisabeth M. Schraner , Bruno M. Humbel, Kurt Tobler , Mathias Ackermann and Andrea S. Laimbacher.  Int J Mol Sci 2017, in press.


2. HSV-1 amplicon vectors launch the production of heterologous rotavirus-like particles and induce rotavirus-specific immune responses in mice. Laimbacher AS, Esteban LE, Castello AA, Abdusetir Cerfoglio JC, Argüelles MH, Glikmann G, D'Antuono A, Mattion N, Berois M, Arbiza J, Hilbe M, Schraner EM, Seyffert M, Dresch C, Epstein AL, Ackermann M, Fraefel C. Mol Ther. 2012 Sep;20(9):1810-20. doi: 10.1038/mt.2012.108.


3. HSV-1 amplicon vectors that direct the in situ production of foot-and-mouth disease virus antigens in mammalian cells can be used for genetic immunization. D'Antuono A, Laimbacher AS, La Torre J, Tribulatti V, Romanutti C, Zamorano P, Quattrocchi V, Schraner EM, Ackermann M, Fraefel C, Mattion N. Vaccine. 2010 Oct 28;28(46):7363-72. doi: 10.1016/j.vaccine.2010.09.011.


4. HSV-1 amplicon-mediated post-transcriptional inhibition of Rad51 sensitizes human glioma cells to ionizing radiation. Saydam O, Saydam N, Glauser DL, Pruschy M, Dinh-Van V, Hilbe M, Jacobs AH, Ackermann M, Fraefel C. Gene Ther. 2007 Aug;14(15):1143-51.


5. Herpes simplex virus 1 amplicon vector-mediated siRNA targeting epidermal growth factor receptor inhibits growth of human glioma cells in vivo. Saydam O, Glauser DL, Heid I, Turkeri G, Hilbe M, Jacobs AH, Ackermann M, Fraefel C. Mol Ther. 2005 Nov;12(5):803-12.


6. In vivo gene transfer to the rat retina using herpes simplex virus type 1 (HSV-1)-based amplicon vectors. Fraefel C, Mendes-Madeira A, Mabon O, Lefebvre A, Le Meur G, Ackermann M, Moullier P, Rolling F. Gene Ther. 2005 Aug;12(16):1283-8.


7. Update on herpesvirus amplicon vectors. Oehmig A, Fraefel C, Breakefield XO. Mol Ther. 2004 Oct;10(4):630-43. Review.


8. BAC-VAC, a novel generation of (DNA) vaccines: A bacterial artificial chromosome (BAC) containing a replication-competent, packaging-defective virus genome induces protective immunity against herpes simplex virus 1. Suter M, Lew AM, Grob P, Adema GJ, Ackermann M, Shortman K, Fraefel C. Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12697-702


9. Herpes simplex virus type 1 DNA amplified as bacterial artificial chromosome in Escherichia coli: rescue of replication-competent virus progeny and packaging of amplicon vectors. Saeki Y, Ichikawa T, Saeki A, Chiocca EA, Tobler K, Ackermann M, Breakefield XO, Fraefel C. Hum Gene Ther. 1998 Dec 10;9(18):2787-94.


10. Helper virus-free transfer of herpes simplex virus type 1 plasmid vectors into neural cells.

Fraefel C, Song S, Lim F, Lang P, Yu L, Wang Y, Wild P, Geller AI. J Virol. 1996 Oct;70(10):7190-7.