Publications 2014 -


Serine administration as a novel prophylactic approach to reduce the severity of acute pancreatitis during diabetes in mice

Chen Rong, Hornemann Thorsten, Stefanic Sasa, Schraner Elisabeth,
Züllig Richard, Reding Theresia, Malagola Ermanno, Henstridge Darren C, Hills Andrew P, Graf Rolf, Sonda Sabrina

2020 May 8. doi: 10.1007/s00125-020-05156-x. [Epub ahead of print]


Conserved rotavirus NSP5 and VP2 domains interact and affect viroplasm

Buttafuoco A, Michaelsen K, Tobler K, Ackermann M, Fraefel C, Eichwald C

J Virol. 2020 Jan 8. pii: JVI.01965-19. doi: 10.1128/JVI.01965-19


HSV-1 Amplicon Vectors as Genetic Vaccines

Meier A.F. , Laimbacher A.

Methods Mol Biol. 2020;2060:111-130. doi: 10.1007/978-1-4939-9814-2_6.


Intraluminal vesicles of binucleate trophoblast cell granules are a possible source of placental exosomes in ruminants

Karl Klisch, Elisabeth Schraner

Placenta 90 (2020) 58-61,



Recombinant rotaviruses rescued by reverse genetics reveal the role of NSP5 hyperphosphorylation in the assembly of viral factories

Guido Papa, Luca Venditti, Francesca Arnoldi, Elisabeth M. Schraner, Christiaan Potgieter, Alexander Borodavka, Catherine Eichwald, Oscar R. Burronoe

JVI.01110-19. doi: 10.1128/JVI.01110-19


The guanine nucleotide exchange factor GBF1 participates in rotavirus replication

José L. Martínez, Francesca Arnoldib, Elisabeth M. Schraner, Catherine Eichwald,Daniela Silva-Ayala, Eunjoo Lee, Elizabeth Sztul, Óscar R. Burrone, Susana López,and Carlos F. Arias

J Virol. 2019 Jul 3. pii: JVI.01062-19. doi: 10.1128/JVI.01062-19. (Epub ahead of print)


Evolutionary implications of fetal and maternal microvillous surfaces in epitheliochorial placentae

Kazemian A, Hooshmandabbasi R, Schraner EM, Boos A, Klisch K.

J Morphol. 2019 Feb 25. doi: 10.1002/jmor.20970 (Epub ahead of print)


Nuclear envelope impairment is facilitated by the herpes simplex virus 1 Us3 kinase.

Peter Wild, Sabine Leisinger, Anna Paula de Oliveira, Jana Doehner, Elisabeth M. Schraner, Cornel Fraevel, Mathias Ackermann, Andres Kaech

F1000 Res. DOI: 10.12688/f1000research.17802.1


The Cyclin-Dependent Kinase 5 Inhibitor Peptide Inhibits Herpes Simplex Virus Type 1 Replication.

Adrian Man, Mark Slevin, Eugen Petcu, Cornel Fraefel

Sci Rep. 2019 Feb 4;9(1):1260. doi: 10.1038/s41598-018-37989-3.


Mouse intestinal microbiota reduction favors local intestinal immunity triggered
by antigens displayed in Bacillus subtilis biofilm.

Cédric M. Vogt, Monika Hilbe, Mathias Ackermann, Claudio Aguilar, Catherine Eichwald

Microb Cell Fact. 2018 Nov 26;17(1):187. doi: 10.1186/s12934-018-1030-8.


Characterization of Haartman Institute snake virus-1 (HISV-1) and HISV-like viruses-The representatives of genus hartmanivirus, family Arenaviridae.

Hepojoki J, Hepojoki S, Smura T, Szirovicza L, Dervas E, Prähauser B, Nufer L, Schraner EM, Vapalahti O, Kipar A, Hetzel U.

PLoS Pathog. 2018 Nov 14;14(11):e1007415. doi: 10.1371/journal.ppat.1007415. [Epub ahead of print]


MxB is an interferon-induced restriction factor of human herpesviruses.

Michel Crameri, Michael Bauer, Nicole Caduff, Raphael Walker, Fiona Steiner, Francesca D. Franzoso, Cornelia Gujer, Karin Boucke, Talissa Kucera, Andrea Zbinden, Christian Münz, Cornel Fraefel, Urs F. Greber, Jovan Pavlovic,

nature communicatins, 2018 Nat Commun. 2018 May 17;9(1):1980. doi: 10.1038/s41467-018-04379-2.


The dynamics of both filamentous and globular mammalian reovirus viral factories rely on the microtubule network.

Eichwald C, Ackermann M, Nibert ML.

Virology.2018 May;518:77-86. doi: 10.1016/j.virol.2018.02.009. Epub 2018 Feb 20.


Evaluation of the immunogenicity of a recombinant HSV-1 vector expressing human group C rotavirus VP6 protein.

Rota RP, Palacios CA, Temprana CF, Argüelles MH, Mandile MG, Mattion N, Laimbacher AS, Fraefel C4, Castello AA, Glikmann G.

J Virol Methods. 2018 Jun;256:24-31. doi: 10.1016/j.jviromet.2018.02.020. Epub 2018 Feb 27.


Mutant torsinA in the heterozygous DYT1 state compromises HSV propagation in infected neurons and fibroblasts.

György B., Cruz L., Yellen D., Aufiero M., Alland I., Zhang X., Ericsson M., Fraefel C., Li YC., Takeda S., Hyman BT., Breakefield XO.

Sci Rep. 2018 Feb 2;8(1):2324. doi: 10.1038/s41598-018-19865-2.


Oral application of 1  recombinant Bacillus subtilis  spores to dogs results in a humoral response against specific Echinococcus granulosus  paramyosin and tropomyosin antigens.

Cédric M. Vogt, Maria Teresa Armúa-Fernández, Kurt Tobler , Monika Hilbe, Claudio Aguilar, Mathias Ackermann, Peter Deplazes, and Catherine Eichwald.

Infect Immun. 2017 Dec 11. [Epub ahead of print]


Actin-dependent non-lytic rotavirus exit and infectious virus morphogenetic pathway in non-polarized cells.

Oscar Trejo-Cerro, Catherine Eichwald, Elisabeth M. Schraner, Daniela Silva-Ayala, Susana Lopez, Carlos F. Arias. 

J Virol. 2017 Dec 20 [Epub ahead of print]


Identification of a small molecule that compromises the structural integrity of viroplasms and rotavirus double-layered particles.
Eichwald C, De Lorenzo G, Schraner EM, Papa G, Bollati M, Swuec P, de Rosa M, Milani M, Mastrangelo E, Ackermann M, Burrone OR, Arnoldi F

J Virol. 2017 Nov 15. pii: JVI.01943-17. doi: 10.1128/JVI.01943-17. [Epub ahead of print]


Saporin-conjugated tetramers identify efficacious anti-HIV CD8+ T-cell specificities.

Ellen M. Leitman, Christine D. Palmer, Søren Buus, Fabian Chen, Lynn Riddell,
Stuart Sims, Paul Klenerman, Asier Sáez-Cirión, Bruce D. Walker, Paul R. Hess,
Marcus Altfeld, Philippa C. Matthews, Philip J. R. Goulder

PLoS One. 2017 Oct 11;12(10):e0184496. doi: 10.1371/journal.pone.0184496. eCollection 2017.


Dissection of mammalian orthoreovirus µ2 reveals a self-associative domain required for binding to microtubules but not to factory matrix protein µNS.

Eichwald C, Kim J, Nibert ML.

PLoS One. 2017 Sep 7;12(9):e0184356. doi: 10.1371/journal.pone.0184356. eCollection 2017. PMID:28880890


Rotavirus replication is correlated with S/G2 interphase arrest of the host cell cycle.

Glück S, Buttafuoco A, Meier AF, Arnoldi F, Vogt B, Schraner EM, Ackermann M, Eichwald C.

PLoS One. 2017 Jun 16;12(6):e0179607. doi: 10.1371/journal.pone.0179607. eCollection 2017. PMID:28622358


Endoplasmic reticulum-to-Golgi transitions upon herpes virus infection.

Peter Wild, Andres Kaech, Elisabeth Schraner, Ladina Walser, Mathias Ackermann

F1000Research 2017, 6:1804 (doi: 10.12688/f1000research.12252.1)


Zellzyklusspezifische Genexpression des Adeno-assoziierten Virus. 

S. O. Sutter, C. Fraefel, A. F. Meier

Biospektrum, 06 17.,DOI: 10.1007/s12268-017-0853-x, © Springer-Verlag 2017


MyD88-dependent pro-interleukin-1β induction in dendritic cells exposed to food-grade synthetic amorphous silica.

Winkler HC, Kornprobst J, Wick P, von Moos LM, Trantakis I, Schraner EM, Bathke B, Hochrein H, Suter M, Naegeli H.

Part Fibre Toxicol. 2017 Jun 23;14(1):21. doi: 10.1186/s12989-017-0202-8. PMID:28645296


Recombinant Modified Vaccinia Virus Ankara Generating Ebola Virus-Like Particles.

Schweneker M, Laimbacher AS, Zimmer G, Wagner S, Schraner EM, Wolferstätter M, Klingenberg M, Dirmeier U, Steigerwald R, Lauterbach H, Hochrein H, Chaplin P, Suter M, Hausmann J.

J Virol. 2017 May 12;91(11). pii: e00343-17. doi: 10.1128/JVI.00343-17. Print 2017 Jun 1. PMID:28331098


U94 of human herpesvirus 6 down-modulates Src, promotes a partial mesenchymal-to-epithelial transition and inhibits tumor cell growth, invasion and metastasis.

Caccuri F, Ronca R, Laimbacher AS, Berenzi A, Steimberg N, Campilongo F, Mazzuca P, Giacomini A, Mazzoleni G, Benetti A, Caselli E, Presta M, Di Luca D, Fraefel C, Caruso A.

Oncotarget. 2017 May 11. doi: 10.18632/oncotarget.17817. [Epub ahead of print]


Cell cycle-dependent expression of AAV2 Rep in HSV-1 co-infections gives rise to a mosaic of cells replicating either AAV2 or HSV-1

Franzoso FD, Seyffert M, Vogel R, Yakimovich A, de Andrade Pereira B, Meier AF, Sutter SO, Tobler K, Vogt B, Greber UF, Büning H, Ackermann M, Fraefel C.

J Virol. 2017 May 17. pii: JVI.00357-17. doi: 10.1128/JVI.00357-17. [Epub ahead of print]


Transfer of Anti-Rotavirus Antibodies during Pregnancy and in Milk Following Maternal Vaccination with a Herpes Simplex Virus Type-1 Amplicon Vector.

International Journal of Molecular Sciences 18.  Meier, A.F., Suter, M., Schraner, E.M., Humbel, B.M., Tobler, K., Ackermann, M., and Laimbacher, A.S. (2017)

International Journal of Molecular Sciences 18


Novel Mutant AAV2 Rep Proteins Support AAV2 Replication without Blocking HSV-1 Helpervirus Replication.

Seyffert M, Glauser DL, Schraner EM, de Oliveira AP, Mansilla-Soto J, Vogt B, Büning H, Linden RM, Ackermann M, Fraefel C.

PLoS One. 2017 Jan 26;12(1):e0170908. doi: 10.1371/journal.pone.0170908.


IFN-γ Primes Keratinocytes for HSV-1-Induced Inflammasome Activation.

Strittmatter GE, Sand J, Sauter M, Seyffert M, Steigerwald R, Fraefel C, Smola S, French LE, Beer HD.

J Invest Dermatol. 2016 Mar;136(3):610-20. doi: 10.1016/j.jid.2015.12.022. Epub 2015 Dec 29.


Adenovirus Specific Pre-Immunity Induced by Natural Route of Infection Does Not Impair Transduction by Adenoviral Vaccine Vectors in Mice.

de Andrade Pereira B, E Maduro Bouillet L, Dorigo NA, Fraefel C, Bruna-Romero O.

PLoS One. 2015 Dec 17;10(12):e0145260. doi: 10.1371/journal.pone.0145260. eCollection 2015.


Novel immunotherapeutic approaches in targeting dendritic cells with virus vectors.

de Andrade Pereira B, Fraefel C.

Discov Med. 2015 Sep;20(109):111-9.


Adeno-Associated Virus Type 2 Rep68 Can Bind to Consensus Rep-Binding Sites on the Herpes Simplex Virus 1 Genome.

Seyffert M, Glauser DL, Tobler K, Georgiev O, Vogel R, Vogt B, Agúndez L, Linden M, Büning H, Ackermann M, Fraefel C.

J Virol. 2015 Nov 1;89(21):11150-8. doi: 10.1128/JVI.01370-15. Epub 2015 Aug 19.


Tolerance of activated pathogenic CD4+ T cells by transcriptional targeting of dendritic cells.
de Andrade Pereira B, Ackermann M, Chaudhary S, Vogel R, Vogt B, Dresch C, Fraefel C.
Gene Ther. 2015 May;22(5):382-90. doi: 10.1038/gt.2015.6. Epub 2015 Mar 5.

Herpes simplex virus type 1 (HSV-1)-derived amplicon vectors for gene transfer and gene therapy.
Fraefel C, Marconi P, Epstein AL.
Methods Mol Biol. 2015;1254:295-316. doi: 10.1007/978-1-4939-2152-2_21.

Herpes simplex virus type 1 (HSV-1)-derived recombinant vectors for gene transfer and gene therapy.

Marconi P, Fraefel C, Epstein AL.
Methods Mol Biol. 2015;1254:269-93. doi: 10.1007/978-1-4939-2152-2_20.


Infectious delivery of alphaherpesvirus bacterial artificial chromosomes.

Tobler K, Fraefel C.
Methods Mol Biol. 2015;1227:217-30. doi: 10.1007/978-1-4939-1652-8_10.

The interaction of the HSV-1 tegument proteins pUL36 and pUL37 is essential for secondary envelopment during viral egress.

Kelly BJ, Bauerfeind R, Binz A, Sodeik B, Laimbacher AS, Fraefel C, Diefenbach RJ.Virology. 2014 Apr;454-455:67-77. doi: 10.1016/j.virol.2014.02.003. Epub 2014 Feb 22.


Multifluorescence live analysis of herpes simplex virus type-1 replication.

Seyffert M, de Oliveira AP, Fraefel C, Vogel R.Methods Mol Biol. 2014;1144:235-47. doi: 10.1007/978-1-4939-0428-0_16.PMID: 24671688 [PubMed - in process]


HSV-1 amplicon vectors as genetic vaccines.

Laimbacher AS, Fraefel C.Methods Mol Biol. 2014;1144:99-115. doi: 10.1007/978-1-4939-0428-0_7.PMID: 24671679 [PubMed - in process]


Herpes simplex virus type 1 (HSV-1)-derived amplicon vectors.

Melendez ME, Fraefel C, Epstein AL.Methods Mol Biol. 2014;1144:81-98. doi: 10.1007/978-1-4939-0428-0_6.PMID: 24671678 [PubMed - in process]


The potential application of a transcriptionally regulated oncolytic herpes simplex virus for human cancer therapy.

Miao L, Fraefel C, Sia KC, Newman JP, Mohamed-Bashir SA, Ng WH, Lam PY.Br J Cancer. 2014 Jan 7;110(1):94-106. doi: 10.1038/bjc.2013.692. Epub 2013 Nov 5.PMID: 24196790 [PubMed - indexed for MEDLINE]