Establishment of a Three-Dimensional in vitro Model of Equine Papillomavirus Type 2 Infection

Anne Sophie Ramsauer, Garrett Louis Wachoski-Dark, Cornel Fraefel, Mathias Ackermann, Sabine Brandet, Paula Grest, Cameron Greig Knight, Claude Favrot, Kurt Tobler

Equine sarcoids in captive wild equids: Diagnostic and clinical management of 16 cases - a possible predisposition of the European cohort of Somali wild ass (Equus Africanus Somaliensis)?

Paving the way for more precise diagnosis of EcPV2-associated equine penile lesions

Anne Sophie Ramsauer, Garrett Louis Wachoski-Darf, Cornel Fraefel, Kurt Tobler, Sabine Brandt, Cameron Greig Knight, Claude Favrot and Paula Grest

BMC Vet Res. 2019 Oct 22;15(1):356. doi: 10.1186/s12917-019-2097-0.


RNA-seq analysis in equine papillomavirus type 2-positive carcinomas identifies affected pathways and potential cancer markers as well as viral gene expression and splicing events RNA-seq analysis in equine papillomavirus type 2-positive carcinomas identifies affected pathways and potential cancer markers as well as viral gene expression and splicing events

Anna Sophie Ramsauer, Jakub Kubacki, Claude Favrot , Mathias Ackermann , Cornel Fraefel and Kurt Tobler,

J Gen Virol. 2019 Jun;100(6):985-998. doi: 10.1099/jgv.0.001267


Complete Genome Sequence of a Boa (Boa constrictor)-Specific Papillomavirus Type 1 Isolate.

Kubacki J, Ramsauer AS, Bachofen C, Favrot C, Nicolier A, Fraefel C, Tobler K.

Microbiol Resour Announc. 2018 Oct 25;7(16). pii: e01159-18. doi: 10.1128/MRA.01159-18. eCollection 2018 Oct.


Detection and Characterization of Okapi (Okapia johnstoni)—specific Papillomavirus type 1 (OjPV1).

Anna Sophie Ramsauer, Jakub Kubacki, Monika Welle, Claudia Bachofen, Cornel Fraefel, Stefan Hoby, Kurt Tobler, Christian Wenker

Microbiol Resour Announc. 2018 Oct 25;7(16). pii: e01159-18. doi: 10.1128/MRA.01159-18. eCollection 2018 Oct.


Genomic comparison of bovine papillomavirus 1 isolates from bovine,
equine and asinine lesional tissue samples

C. Koch, A.S. Ramsauer, M. Drögemüller, M. Ackermann, V. Gerber, K. Tobler

Virus Res. 2017 Nov 4. pii: S0168-1702(17)30337-4. doi: 10.1016/j.virusres.2017.11.005. [Epub ahead of print]


Feline sarcoid in a 1-year-old domestic short-haired cat caused by bovine papillomavirus type 14 in Switzerlan].

Kiefer C, Tobler K, Ramsauer A, Biegel U, Kuehn N, Ruetten M.

Schweiz Arch Tierheilkd. 2017 Sep;159(9):487-491. doi: 10.17236/sat00127. French.PMID:28952958


Meier AF, Suter M, Schraner EM, Humbel BM, Tobler K, Ackermann M, Laimbacher
AS. Transfer of Anti-Rotavirus Antibodies during Pregnancy and in Milk Following
Maternal Vaccination with a Herpes Simplex Virus Type-1 Amplicon Vector. Int J
Mol Sci. 2017 Feb 16;18(2). pii: E431. doi: 10.3390/ijms18020431. PubMed PMID:
28212334; PubMed Central PMCID: PMC5343965.


Geisseler M, Lange CE, Favrot C, Fischer N, Ackermann M, Tobler K. Geno- and
seroprevalence of Felis domesticus Papillomavirus type 2 (FdPV2) in
dermatologically healthy cats. BMC Vet Res. 2016 Jul 22;12(1):147. doi:
10.1186/s12917-016-0776-7. PubMed PMID: 27449225; PubMed Central PMCID:

Wild P, Leisinger S, de Oliveira AP, Schraner EM, Kaech A, Ackermann M, Tobler
K. Herpes simplex virus 1 Us3 deletion mutant is infective despite impaired
capsid translocation to the cytoplasm. Viruses. 2015 Jan 12;7(1):52-71. doi:
10.3390/v7010052. PubMed PMID: 25588052; PubMed Central PMCID: PMC4306828.

Tobler K, Fraefel C. Infectious delivery of alphaherpesvirus bacterial
artificial chromosomes. Methods Mol Biol. 2015;1227:217-30. doi:
10.1007/978-1-4939-1652-8_10. PubMed PMID: 25239748.

Lange CE, Vetsch E, Ackermann M, Favrot C, Tobler K. Four novel papillomavirus
sequences support a broad diversity among equine papillomaviruses. J Gen Virol.
2013 Jun;94(Pt 6):1365-72. doi: 10.1099/vir.0.052092-0. Epub 2013 Mar 13. PubMed
PMID: 23486670.

Lange CE, Tobler K, Schraner EM, Vetsch E, Fischer NM, Ackermann M, Favrot C.
Complete canine papillomavirus life cycle in pigmented lesions. Vet Microbiol.
2013 Mar 23;162(2-4):388-95. doi: 10.1016/j.vetmic.2012.10.012. Epub 2012 Oct 16.
PubMed PMID: 23123172.

Lange CE, Tobler K, Lehner A, Grest P, Welle MM, Schwarzwald CC, Favrot C.
EcPV2 DNA in equine papillomas and in situ and invasive squamous cell carcinomas
supports papillomavirus etiology. Vet Pathol. 2013 Jul;50(4):686-92. doi:
10.1177/0300985812463403. Epub 2012 Oct 11. PubMed PMID: 23064881.

Sigrist B, Tobler K, Schybli M, Konrad L, Stöckli R, Cattoli G, Lüschow D,
Hafez HM, Britton P, Hoop RK, Vögtlin A. Detection of Avian coronavirus
infectious bronchitis virus type QX infection in Switzerland. J Vet Diagn Invest.
2012 Nov;24(6):1180-3. doi: 10.1177/1040638712463692. Epub 2012 Oct 10. PubMed
PMID: 23051829.

Lange CE, Ackermann M, Favrot C, Tobler K. Entire genomic sequence of novel
canine papillomavirus type 13. J Virol. 2012 Sep;86(18):10226-7. doi:
10.1128/JVI.01553-12. PubMed PMID: 22923791; PubMed Central PMCID: PMC3446628.

Sutter E, de Oliveira AP, Tobler K, Schraner EM, Sonda S, Kaech A, Lucas MS,
Ackermann M, Wild P. Herpes simplex virus 1 induces de novo phospholipid
synthesis. Virology. 2012 Aug 1;429(2):124-35. doi: 10.1016/j.virol.2012.04.004.
Epub 2012 May 5. PubMed PMID: 22560864.

Wild P, de Oliveira AP, Sonda S, Schraner EM, Ackermann M, Tobler K. The
herpes simplex virus 1 U(S)3 regulates phospholipid synthesis. Virology. 2012 Oct
25;432(2):353-60. doi: 10.1016/j.virol.2012.06.020. Epub 2012 Jul 11. PubMed
PMID: 22789738.

Lange CE, Favrot C, Ackermann M, Gull J, Vetsch E, Tobler K. Novel snake
papillomavirus does not cluster with other non-mammalian papillomaviruses. Virol
J. 2011 Sep 12;8:436. doi: 10.1186/1743-422X-8-436. PubMed PMID: 21910860; PubMed
Central PMCID: PMC3179961.

Lange CE, Tobler K, Lehner A, Vetsch E, Favrot C. A case of a canine
pigmented plaque associated with the presence of a Chi-papillomavirus. Vet
Dermatol. 2012 Feb;23(1):76-80, e18-9. doi: 10.1111/j.1365-3164.2011.01007.x.
Epub 2011 Sep 1. PubMed PMID: 21883544.

Lange CE, Zollinger S, Tobler K, Ackermann M, Favrot C. Clinically healthy
skin of dogs is a potential reservoir for canine papillomaviruses. J Clin
Microbiol. 2011 Feb;49(2):707-9. doi: 10.1128/JCM.02047-10. Epub 2010 Dec 15.
PubMed PMID: 21159938; PubMed Central PMCID: PMC3043500.

Lange CE, Tobler K, Ackermann M, Favrot C. Identification of two novel equine
papillomavirus sequences suggests three genera in one cluster. Vet Microbiol.
2011 Apr 21;149(1-2):85-90. doi: 10.1016/j.vetmic.2010.10.019. Epub 2010 Nov 4.
PubMed PMID: 21109367.

Gabev E, Tobler K, Abril C, Hilbe M, Senn C, Franchini M, Campadelli-Fiume G,
Fraefel C, Ackermann M. Glycoprotein D of bovine herpesvirus 5 (BoHV-5) confers
an extended host range to BoHV-1 but does not contribute to invasion of the
brain. J Virol. 2010 Jun;84(11):5583-93. doi: 10.1128/JVI.00228-10. Epub 2010 Mar
10. PubMed PMID: 20219909; PubMed Central PMCID: PMC2876591.

Lange CE, Tobler K, Brandes K, Breithardt K, Ordeix L, Von Bomhard W, Favrot
C. Canine inverted papillomas associated with DNA of four different
papillomaviruses. Vet Dermatol. 2010 Jun;21(3):287-91. doi:
10.1111/j.1365-3164.2009.00817.x. Epub 2009 Dec 23. PubMed PMID: 20042038.

Gabev E, Fraefel C, Ackermann M, Tobler K. Cloning of Bovine herpesvirus type
1 and type 5 as infectious bacterial artifical chromosomes. BMC Res Notes. 2009
Oct 14;2:209. doi: 10.1186/1756-0500-2-209. PubMed PMID: 19828032; PubMed Central
PMCID: PMC2770474.

Lange CE, Tobler K, Ackermann M, Panakova L, Thoday KL, Favrot C. Three novel
canine papillomaviruses support taxonomic clade formation. J Gen Virol. 2009
Nov;90(Pt 11):2615-21. doi: 10.1099/vir.0.014498-0. Epub 2009 Aug 5. PubMed PMID:

Richter M, Schudel L, Tobler K, Matheis F, Vögtlin A, Vanderplasschen A,
Costes B, Spiess B, Ackermann M. Clinical, virological, and immunological
parameters associated with superinfection of latently with FeHV-1 infected cats.
Vet Microbiol. 2009 Sep 18;138(3-4):205-16. doi: 10.1016/j.vetmic.2009.03.022.
Epub 2009 Mar 21. PubMed PMID: 19359108.

Lange CE, Tobler K, Markau T, Alhaidari Z, Bornand V, Stöckli R, Trüssel M,
Ackermann M, Favrot C. Sequence and classification of FdPV2, a papillomavirus
isolated from feline Bowenoid in situ carcinomas. Vet Microbiol. 2009 May
28;137(1-2):60-5. doi: 10.1016/j.vetmic.2009.01.002. Epub 2009 Jan 6. PubMed
PMID: 19181460.

Lange CE, Tobler K, Favrot C, Müller M, Nöthling JO, Ackermann M. Detection
of antibodies against epidermodysplasia verruciformis-associated canine
papillomavirus 3 in sera of dogs from Europe and Africa by enzyme-linked
immunosorbent assay. Clin Vaccine Immunol. 2009 Jan;16(1):66-72. doi:
10.1128/CVI.00346-08. Epub 2008 Nov 26. PubMed PMID: 19038784; PubMed Central
PMCID: PMC2620667.

Wild P, Senn C, Manera CL, Sutter E, Schraner EM, Tobler K, Ackermann M,
Ziegler U, Lucas MS, Kaech A. Exploring the nuclear envelope of herpes simplex
virus 1-infected cells by high-resolution microscopy. J Virol. 2009
Jan;83(1):408-19. doi: 10.1128/JVI.01568-08. Epub 2008 Oct 15. PubMed PMID:
18922868; PubMed Central PMCID: PMC2612326.

Zurbriggen S, Tobler K, Abril C, Diedrich S, Ackermann M, Pallansch MA,
Metzler A. Isolation of sabin-like polioviruses from wastewater in a country
using inactivated polio vaccine. Appl Environ Microbiol. 2008 Sep;74(18):5608-14.
doi: 10.1128/AEM.02764-07. Epub 2008 Jul 18. PubMed PMID: 18641161; PubMed
Central PMCID: PMC2547022.

Tobler K, Lange C, Carlotti DN, Ackermann M, Favrot C. Detection of a novel
papillomavirus in pigmented plaques of four pugs. Vet Dermatol. 2008
Feb;19(1):21-5. doi: 10.1111/j.1365-3164.2007.00640.x. PubMed PMID: 18177287.

Tobler K, Favrot C, Nespeca G, Ackermann M. Detection of the prototype of a
potential novel genus in the family Papillomaviridae in association with canine
epidermodysplasia verruciformis. J Gen Virol. 2006 Dec;87(Pt 12):3551-7. PubMed
PMID: 17098970.

Wild P, Engels M, Senn C, Tobler K, Ziegler U, Schraner EM, Loepfe E,
Ackermann M, Mueller M, Walther P. Impairment of nuclear pores in bovine
herpesvirus 1-infected MDBK cells. J Virol. 2005 Jan;79(2):1071-83. PubMed PMID:
15613336; PubMed Central PMCID: PMC538577.

Ackermann M, Engels M, Fraefel C, Metzler A, Schwyzer M, Suter M, Tobler K.
Herpesviruses: balance in power and powers imbalanced. Vet Microbiol. 2002 Apr
22;86(1-2):175-81. Review. PubMed PMID: 11888700.